Phosphorylation and ubiquitination are reversible post-translational modifications with key roles in various signal transduction cascades. Currently, cancer cell-specific metabolic adaptation is a hot issue to be addressed. The mammalian target of rapamycin (mTOR) signaling pathway integrates both intracellular and extracellular signals and serves as a central regulator of cell metabolism, growth, proliferation and survival. The mTOR pathway is activated during various cellular processes such as tumor formation and angiogenesis, insulin resistance, adipogenesis and is deregulated in human diseases such as cancer and diabetes. Although ubiquitination of target protein plays a critical role in other cellular activity during tumorigenesis, little is known about functional relevance of ubiquitin-mediated coordination of mTOR pathway and autophagy induction. So we have interested in the deciphering molecular networks of signaling pathway particularly associated with human diseases caused by malfunction of nutrient sensing.
Education
(PhD) 1995 Department of Molecular Biology, Seoul National University
Experience
2021 - 2022 Dean, College of Science, Sungkyunkwan University
2012 - present Professor, Dept. of Biological Sciences, Sungkyunkwan University
2006 - 2012 Associate Professor, Dept. of Biological Sciences, Sungkyunkwan University
2002 - 2006 Assistant Professor, Dept. of Biological Sciences, Sungkyunkwan University
1997 - 2001 Postdoc., Lab. of Molecular Cardiology, National Institutes of Health, USA
1995 - 1996 Postdoc., Research Center for Cell Differentiation, Seoul National University
2012-present Editorial board member, Biomedical Research International (SCI journal)
Journal Articles
(2023)
L-Type Amino Acid Transporter 1 (LAT1) Promotes PMA-Induced Cell Migration through mTORC2 Activation at the Lysosome.
CELLS.
12,
20
(2021)
Sphingosylphosphorylcholine blocks ovariectomy-induced bone loss by suppressing Ca2+/calmodulin-mediated osteoclast differentiation.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE.
25,
1
(2020)
Tumor-Infiltrating Regulatory T-cell Accumulation in the Tumor Microenvironment Is Mediated by IL33/ST2 Signaling.
CANCER IMMUNOLOGY RESEARCH.
8,
11
(2020)
The Beneficial Effects of Morusin, an Isoprene Flavonoid Isolated from the Root Bark of Morus.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES.
21,
18
(2020)
Blocking of the IL-33/ST2 Signaling Axis by a Single-Chain Antibody Variable Fragment (scFv) Specific to IL-33 with a Defined Epitope.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES.
21,
18
(2020)
Stress Granule Formation Attenuates RACK1-Mediated Apoptotic Cell Death Induced by Morusin.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES.
21,
15
(2019)
The N-Degron Pathway Mediates ER-phagy.
MOLECULAR CELL.
75,
5
(2019)
ARABIDOPSIS TRITHORAX 4 Facilitates Shoot Identity Establishment during the Plant Regeneration Process.
PLANT AND CELL PHYSIOLOGY.
60,
4
(2019)
Functional impairment of the HIPK2 small ubiquitin-like modifier (SUMO)-interacting motif in acute myeloid leukemia.
AMERICAN JOURNAL OF CANCER RESEARCH.
9,
1
(2018)
The deubiquitinating enzyme USP20 stabilizes ULK1 and promotes autophagy initiation.
EMBO REPORTS.
19,
4
(2017)
p300-mediated acetylation increased the protein stability of HIPK2 and enhanced its tumor suppressor function.
SCIENTIFIC REPORTS.
7,
(2017)
Site-specific monoubiquitination downregulates Rab5 by disrupting effector binding and guanine nucleotide conversion.
ELIFE.
6,
(2017)
Autophagy inhibits cell death induced by the anti-cancer drug morusin.
AMERICAN JOURNAL OF CANCER RESEARCH.
7,
3
(2016)
Differential pre-amplification of STR loci for fragmented forensic DNA profiling.
ELECTROPHORESIS.
37,
22
(2016)
PARP1 regulates the protein stability and proapoptotic function of HIPK2.
CELL DEATH & DISEASE.
7,
(2016)
Tumor Suppressor HIPK2 Regulates Malignant Growth via Phosphorylation of Notch1.
CANCER RESEARCH.
76,
16
(2015)
SERBP1 affects homologous recombination-mediated DNA repair by regulation of CtIP translation during S phase.
NUCLEIC ACIDS RESEARCH.
43,
13
(2014)
HIPK2 Modification Code for Cell Death and Survival.
Molecular & Cellular Oncology.
1,
2
(2014)
Optimization of STR locus enrichment for STR profiling of fragmented DNA.
ELECTROPHORESIS.
35,
11
(2014)
Cell cycle-dependent SUMO-1 conjugation to nuclear mitotic apparatus protein (NuMA).
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS.
443,
1
Publications
(2020)
필수유전학.
월드사이언스.
Co-author
(2011)
분자세포생물학(제 6 판).
월드사이언스.
Co-author
(2006)
분자세포생물학-제5판.
월드사이언스.
Solo
(2006)
유전자 혁명과 생명윤리.
전파과학사.
Solo
Patent/Intellectual Property
RAGE 단백질-베타아밀로이드 상호작용 억제제, 및 이를 유효성분으로 함유
하는 베타아밀로이드 집적 관련 질환의 예방 또는 치료용 약학적 조성물.
10-2013-0006149.
20160212.
KOREA, REPUBLIC OF
Conference Paper
(2019)
Stress granule antagonizes cell death induced by anti-cancer drug morusin.
한국분자세포생물학회.
KOREA, REPUBLIC OF
(2018)
Interplay between autophagy and cell death induced by anti-cancer drug morusin.
2018 International Conference for KSMCB.
KOREA, REPUBLIC OF
(2017)
Ubiquitination-mediated regulation of LAT1/SLC7A5 amino acid transporter under nutrient starvation condition.
International protein metabolism and disease conference.
KOREA, REPUBLIC OF
(2016)
Interplay between autophagy and apoptosis induced by anti-cancer drug morusin.
한국통합생물학회.
KOREA, REPUBLIC OF
(2016)
Profiling of fragmented forensic DNA by differential pre-amplification.
한국 유전학회.
KOREA, REPUBLIC OF
(2016)
Autophagy inhibits cell death induced by anti-cancer drug morusin.
한국 분자세포생물학회.
KOREA, REPUBLIC OF
(2015)
Regulation of CtBP-interacting protein expression at S phase of cell cycle.
한국분자세포생물학회.
KOREA, REPUBLIC OF
(2014)
Homeodomain-interacting protein kinase 2 (HIPK2) regulates the epithelial-mesenchymal transition via regulation of Snail stability.
37th Annual meeting of the Molecular Biology Society of Japan.
JAPAN
(2014)
Phosphorylation Dynamics of DNA damage response proteins in response to ionizing radiation.
Korean Society of Molecular and cellular Biology Annual Meeting.
KOREA, REPUBLIC OF
(2014)
Hybridization-mediated locus enrichment for STR analysis of fragmented DNA.
World Forensic festival 2014.
KOREA, REPUBLIC OF
(2014)
DNA profiling of degraded forensic samples by STR locus enrichment.
25th International Symposium on human Identification.
UNITED STATES
(2014)
Role of protein degradation in ATM signaling homeostasis in response to ionizing radiation.
Korean Society of Biochemistry and Molecular Biology Annual Meeting.
KOREA, REPUBLIC OF
(2014)
Abeta transportation across blood brain barrier is mediated by two beta-strand of RAGE.
American Society of Biochemistry and Molecular Biology Annual Meeting.
UNITED STATES
(2014)
HIPK2 regulates double-strand break signaling by controlling WIP1 Phosphatase
at the protein level.
American Society of Biochemistry and Molecular Biology Annual Meeting.
UNITED STATES
(2014)
Regulation of Snail stability by HIPK2-mediated phosphorylation.
American Society of Biochemistry and Molecular Biology Annual Meeting.
UNITED STATES
(2014)
STR analysis of degraded DNA.
International Symposium on Forensic DNA in Law.
KOREA, REPUBLIC OF
(2013)
Inhibition of Ab transport across the blood brain barrier by blocking RAGE-Ab interaction.
International conference of the KSMCB.
KOREA, REPUBLIC OF
(2013)
Role of HIPK2 in homeostatic regulation of DNA damage response by targeting WIP1 phosphatase.
International conference of the KSMCB.
KOREA, REPUBLIC OF
(2013)
Autoinhibitory loop of ATM signaling pathway in response to ionizing radiation.
제68회 한국생물과학협회 정기학술대회.
KOREA, REPUBLIC OF
(2013)
Role of Ras-effector NORE1 in the proteasomal degradation of oncoprotein HIPK1.
2013KSBMB Annual Meeting.
KOREA, REPUBLIC OF
